Antimicrobial Activity and Phytochemical Analysis of Coriander sativum Against Infectious Diarrhea

The preliminary phytochemical study and invitro antimicrobial activity of Coriander sativum (Apiaceae) was investigated against some pathogens isolated from patients with infectious diarrhea. The various solvents extract like aqueous, methanol, chloroform, petroleum ether and hexane were screened for antimicrobial activity against Enterotoxigenic E.coli, Enteropathogenic E.coli,, Salmonella typhimurium, Salmonella entertidis, Shigella dysentriae, Shigella flexineri, Candida albicans, Candida tropicalis and Candida krusei isolated from diarrhoeal patients. The preliminary phytochemical analysis of the methanol extracts of the plant showed the presence of carbohydrates, flavonoids, aminoacids, steroids, sterols, saponins and tannins. The extracts were subjected for antimicrobial activity against at 200mg/ml concentration by disc diffusion method. The results of antimicrobial activity revealed that methanol extract of the plant exhibit good activity compared to chloroform and aqueous extracts to E.coli, Salmonella sp and Shigella sp. Petroleum ether and hexane extracts did not show any activity. None of extracts exhibits antifungal activity. The antimicrobial activities of extracts were compared with standard antibiotics.